I stumbled an interesting project called "Animal Controlled Computer Games" on pixelsix:
Animal Controlled Computer Games is the graduation project from Wim van Eck (...) In his project he build a Pacman game, in that the player can play Pacman against real crickets, that controls the ghosts in the Pacman maze. By doing this he analyzes the advantages and disadvantages of real-time behaviour of live animals in comparison to behavior-generating code in computer games.
A paper about it will be presented at ICEC 2006.