Heard in "No Maps for Those Territories" (doc interview of William Gibson):

"when those events occur, it changes the nature of the game; another example and maybe a better one is when it was confirmed that Michael Jackson was going to marry Elvis Presley's daughter, a good friend of mine in the States faxed me, and said 'this made your job more difficult' and I knew exactly what he meant"

What he means is if that is the world, what can he does to make the world more fantastic in his novels.